| Description | Senktide acetate (Senktide acetate(106128-89-6 free base)) is a selective tachykinin NK3 receptor agonist that promotes the consolidation or expression of ELM for the study of Alzheimer's disease. |
| In vitro | Senktide 作为一种选择性 NK3 受体激动剂，以浓度依赖性方式兴奋多个黑质致密部的多巴胺能神经元，其有效作用浓度范围在 3 至 3000 nM之间。平均 EC50 为 41.2±9 nM [1]。 |
| In vivo | Senktide 这种激动剂通过脑室内注射的方式，剂量依赖地诱导超动行为[2]。 |
| Synonyms | Senktide acetate(106128-89-6 free base) |
| molecular weight | 902.02 |
| Molecular formula | C42H59N7O13S |
| Storage | store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Keegan KD, et al. The selective NK3 receptor agonist senktide excites a subpopulation of dopamine-sensitiveneurones in the rat substantia nigra pars compacta in vitro. Br J Pharmacol. 1992 Jan;105(1):3-5. 2. Nordquist RE, et al. The tachykinin NK3 receptor agonist senktide induces locomotor activity in male Mongolian gerbils. Eur J Pharmacol. 2008 Dec 14;600(1-3):87-92. |