| Description | SCP1-IN-1 (compound SH T-62) is a potent and selective covalent inhibitor against SCP1. SCP1-IN-1 promotes REST degradation and reduces transcriptional activity. In some glioblastoma cells, the high level of REST protein drives tumor growth. SCP1-IN-1 has the potential for the research of glioblastoma whose growth is driven by REST transcription activity [1]. |
| molecular weight | 520.5 |
| Molecular formula | C20H19F3N2O7S2 |
| CAS | 2764615-55-4 |
| Storage | store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 90 mg/mL (172.9 mM), Sonication is recommended. |
| References | 1. Medellin B, et al. Targeted Covalent Inhibition of Small CTD Phosphatase 1 to Promote the Degradation of the REST Transcription Factor in Human Cells. J Med Chem. 2022;65(1):507-519. |