| Description | HHS-0701 is a sulfur-triazole exchange (SuTEx) ligand. HHS-0701 is a potent inhibitor of tyrosine-reactive prostaglandin reductase 2 (PTGR2). HHS-0701 can block PTGR2 metabolism of the lipid substrate 15-Keto-PGE2. |
| In vitro | HHS-0701 (0.1, 0.25, 0.5, 1, 2.5, 5, 10, 25 μM；2小时) 在处理过表达PTGR2的重组HEK293T细胞时，实现了依赖浓度的探针标记阻断[1]。 |
| molecular weight | 396.46 |
| Molecular formula | C20H20N4O3S |
| CAS | 2851993-91-2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 3.96 mg/mL (10 mM) |
| References | 1. Emmanuel K Toroitich, et al.Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. |