| Description | SC75741 is a potent P65 inhibitor with IC50 of 200 nM |
| In vitro | SC75741通过抑制人类PBMC增殖，展现出免疫抑制活性，IC50为2.2 μM。[1] 同时，SC75741通过在转录水平上抑制NF-κB介导的信号传导，抑制甲型和乙型流感病毒的复制。此外，SC75741在抵抗病毒变种发展方面表现出高阻力。[2] |
| In vivo | SC75741（15 mg/kg i.p.）在小鼠感染H5N1流感病毒后，能有效减少小鼠肺部的病毒复制和细胞因子表达。[2] |
| Cell experiments | Cell viability assay is prepared using a CellTiter-BluTM Cell Viability Assay. For each concentration of the compound four replicates are measured.(Only for Reference) |
| Target activity | NF-κB:200 nM(EC50) |
| molecular weight | 565.67 |
| Molecular formula | C29H23N7O2S2 |
| CAS | 913822-46-5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | H2O: < 1 mg/mL (insoluble or slightly soluble) DMSO: 50 mg/mL (88.39 mM) Ethanol: < 1 mg/mL (insoluble or slightly soluble) |
| References | 1. Leban J, et al. Bioorg Med Chem Lett. 2007, 17(21), 5858-5862. 2. Ehrhardt C, et al. Cell Microbiol. 2013, 15(7), 1198-1211. 3. Hu, Qiuhui, Hengjun Du, Gaoxing Ma, Fei Pei, Ning Ma, Biao Yuan, Paul A. Nakata, and Wenjian Yang. Purification, identification and functional characterization of an immunomodulatory protein from Pleurotus eryngii [J]. Food Funct. 2018 Jul 17;9(7):3764-3775. |
| Citations | 1. Zhou D, Yang S, Yan H, et al. SC75741, a novel c-Abl inhibitor, promotes the clearance of TDP25 aggregates via ATG5-dependent autophagy pathway. Frontiers in Pharmacology. 2021: 2891. 2. Hu Q, Du H, Ma G, et al. Purification, identification and functional characterization of an immunomodulatory protein from Pleurotus eryngii. Food & Function. 2018, 9(7): 3764-3775 3. Su J, Yin W, Huo M, et al.Induction of apoptosis in glioma cells by lycorine via reactive oxygen species generation and regulation of NF-κB pathways.Naunyn-Schmiedeberg's Archives of Pharmacology.2023: 1-9. 4. Geng R, Zhao Y, Xu W, et al.SIRPB1 regulates inflammatory factor expression in the glioma microenvironment via SYK: functional and bioinformatics insights.Journal of Translational Medicine.2024, 22(1): 338 5. Zheng M, Zhai Y, Yu Y, et al.TNF compromises intestinal bile-acid tolerance dictating colitis progression and limited infliximab response.Cell Metabolism.2024 |