| Description | SB236057 is a potent and selective inverse agonist for the 5-HT receptor, acting especially at 5-HT autoreceptors on nerve terminals. It produces a rapid increase in 5-HT levels in the brain. SB236057 also acts as a potent teratogen, producing severe musculoskeletal birth defects when rodents were exposed to it during pregnancy. |
| Synonyms | SB-236057, SB 236057 |
| molecular weight | 534.65 |
| Molecular formula | C33H34N4O3 |
| CAS | 180083-49-2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Middlemiss DN, Göthert M, Schlicker E, Scott CM, Selkirk JV, Watson J, Gaster LM, Wyman P, Riley G, Price GW. SB-236057, a selective 5-HT1B receptor inverse agonist, blocks the 5-HT human terminal autoreceptor. European Journal of Pharmacology. 1999;375(1-3):359-65. PMID 10443589 2. Roberts C, Watson J, Price GW, Middlemiss DN. SB-236057-A: a selective 5-HT1B receptor inverse agonist. CNS Drug Reviews. 2001;7(4):433-44. PMID 11830759 |