| Description | MS117 is a first-in-class and cell-active irreversible covalent inhibitor of protein arginine methyltransferase 6 (PRMT6) (IC50 = 18 nM) [1]. |
| In vitro | MS117 (Compound 4) inhibits the PRMT6 methyltransferase activity in a time-dependent manner [1]. MS117 (Compound 4) shows moderate selectivity (6-fold) for PRMT6 over PRMT1 (IC 50 = 0.1 ± 0.025 μM) and PRMT8 (IC 50 = 0.11 ± 0.01 μM) [1]. |
| molecular weight | 298.38 |
| Molecular formula | C17H22N4O |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |