| Description | SB 328437 ((S)-methyl 2-(1-naphthamido)-3-(4-nitrophenyl)propanoate) is an effective and selective antagonist of CCR3 (IC50 = 4.5 nM). |
| Target activity | CCR3:4.5 nM (IC50) |
| Synonyms | (S)-methyl 2-(1-naphthamido)-3-(4-nitrophenyl)propanoate, ZINC29222893 |
| molecular weight | 378.38 |
| Molecular formula | C21H18N2O5 |
| CAS | 247580-43-4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 100 mg/mL (264.3 mM), Sonication is recommended. |
| References | 1. White JR, et al. Identification of potent, selective non-peptide CC chemokine receptor-3 antagonist that inhibits eotaxin-, eotaxin-2-, and monocyte chemotactic protein-4-induced eosinophil migration. J Biol Chem. 2000 Nov 24;275(47):36626-31. |