| Description | JTV-519 Formate is a Ca2+-dependent blocker of sarcoplasmic reticulum Ca2+-stimulated ATPase (SERCA). JTV-519 Formate is also a partial agonist of ryanodine receptors in striated muscle. JTV-519 Formate exhibits antiarrhythmic and cardioprotective properties. |
| In vitro | JTV-519 Formate 能够抑制FK506处理的、共表达RyR2和FKBP12.6的HEK-293细胞中的自发Ca2+释放。而且，K201在仅表达RyR2的HEK-293细胞以及共表达RyR2和FKBP12.6的细胞中以相同的效力抑制自发Ca2+释放。[2] |
| Synonyms | JTV-519 Formate (145903-06-6 Free base) |
| molecular weight | 470.62 |
| Molecular formula | C26H34N2O4S |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Donald J Hunt, et al. K201 (JTV519) suppresses spontaneous Ca2+ release and [3H]ryanodine binding to RyR2 irrespective of FKBP12.6 association. Biochem J. 2007 Jun 15;404(3):431-8. 2. Y-J Chen, et al. Effect of K201, a novel antiarrhythmic drug on calcium handling and arrhythmogenic activity of pulmonary vein cardiomyocytes. Br J Pharmacol. 2008 Mar;153(5):915-25. |