| Description | Sari 59-801 is a novel, orally effective hypoglycemic compound that appears to act largely by stimulation of insulin release. SARI-59-801 was more potent in producing hypoglycemia (ED25 = 47 mg/kg) than their lean littermates (ED25 = 131 mg/kg). |
| In vivo | 在禁食小鼠中，2小时降糖ED25为110 mg/kg；同时，血浆胰岛素水平有所上升，其ED50为47 mg/kg。在禁食大鼠中，口服Sari 59-801 2小时后观察到显著的降糖活性（ED25 = 86 mg/kg），而100 mg/kg的剂量可使血浆胰岛素水平提高62%。 |
| Synonyms | Sari-59-801 |
| molecular weight | 313.39 |
| Molecular formula | C18H23N3O2 |
| CAS | 80565-58-8 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 65 mg/mL (207.41 mM) |
| References | 1. Hanson RL, Isaacson CM. Stimulation of insulin secretion from isolated rat islets by SaRI 59-801. Relation to cAMP concentration and Ca2+ uptake. Diabetes. 1985 Jul;34(7):691-5. PubMed PMID: 2408949. 2. Hanson RL, Isaacson CM, Boyajy LD. Stimulation of insulin secretion from isolated rat islets by SaRI 59-801. Diabetes. 1985 Jun;34(6):548-52. PubMed PMID: 3924691. |