| Description | [Sar9,Met(O2)11]-Substance P (NA) is an agonist of NK1 receptor. |
| Synonyms | Bhsar-sp, NA, 精氨酰-脯氨酰-赖氨酰-脯氨酰-谷氨酰-谷氨酰-苯丙氨酰-苯丙氨酰-SAR-亮氨酸-蛋氨酸[O2]-胺 |
| molecular weight | 1393.66 |
| Molecular formula | C64H100N18O15S |
| CAS | 110880-55-2 |
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | H2O: 50 mg/mL (35.88 mM), Sonication is recommended. |
| References | 1. Dam T V , Martinelli B , Rémi Quirion. Autoradiographic distribution of brain neurokinin-1/substance P receptors using a highly selective ligand [ 3H]-[Sar 9,Met(O 2) 11]-substance P[J]. Brain Research, 1990, 531(1):333-337. 2. WILEY, R. G , KLINE, et al. Anti-nociceptive effects of selectively destroying substance P receptor-expressing dorsal horn neurons using [Sar9, Met(O2)11]-SUBSTANCE P-saporin: Behavioral and anatomical analyses[J]. neuroscience, 2007, 146(3):1333-1345. 3. Cellier E, et al. Characterization of central and peripheral effects of septide with the use of five tachykinin NK1 receptor antagonists in the rat. Br J Pharmacol. 1999 Jun;127(3):717-28. |