| Description | Neurokinin A (NKA), formerly known as Substance K, is a neurologically active peptide translated from the pre-protachykinin gene. |
| In vitro | Neurokinin A（Substance K）是属于tachykinin家族的肽类神经递质，其在人类的气道和胃肠组织中具有重要的调节作用潜力。通过与位于平滑肌细胞上的NK-2受体结合，并与GTP结合蛋白在药理上耦合，Neurokinin A发挥作用。作为tachykinins家族成员之一，这类肽类神经递质在中枢和周围神经系统中广泛分布，并展现出广泛的组织分布特性。tachykinins共有特定的COOH-末端结构Phe-X-Gly-Leu-Met-NH2。在该家族最为人知的成员包括Substance P和Neurokinin A（即Substance K[1]）。 |
| Synonyms | α-Neurokinin, Substance K, 神经激肽A, Neuromedin L |
| molecular weight | 1133.32 |
| Molecular formula | C50H80N14O14S |
| CAS | 86933-74-6 |
| Storage | keep away from moisture|Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | H2O: 100 mg/mL (88.24 mM), Sonication is recommended. |
| References | 1. Gerard NP, et al. The human neurokinin A (substance K) receptor. Molecular cloning of the gene, chromosome localization, and isolation of cDNA from tracheal and gastric tissues. J Biol Chem. 1990 Nov 25;265(33):20455-62. |