| Description | [Sar9,Met(O2)11]-Substance P acetate is a tachykinin NK1 receptor selective agonist. [Sar9,Met(O2)11]-Substance P acetate is a selective tachykinin NK1 receptor agonist.[Sar9,Met(O2)11]-Substance P acetate and septide (10-100 pmol per rat, i.c.v.) are equipotent in increasing mean arterial blood pressure (MAP) and heart rate (HR), yet they have dissimilar time-course. Both agonists increase dose-dependently face washing and sniffing while [Sar9,Met(O2)11]-Substance P acetate is the sole to produce grooming. |
| In vitro | [Sar9,Met(O2)11]-Substance P 和 septide (10-100pmol 每鼠, i.c.v.) 在提高平均动脉血压（MAP）和心率（HR）方面具有同等效力，但它们在作用时间上存在差异。这两种激动剂均能剂量依赖性地增加洗脸和嗅探行为，而仅有 [Sar9,Met(O2)11]-Substance P 能引发梳理行为[1]。 |
| Synonyms | [Sar9,Met(O2)11]-Substance P acetate(110880-55-2 free base) |
| molecular weight | 1467.75 |
| Molecular formula | C67H106N18O17S |
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 10 mM |
| References | 1. Cellier E, et al. Characterization of central and peripheral effects of septide with the use of five tachykinin NK1 receptor antagonists in the rat. Br J Pharmacol. 1999 Jun;127(3):717-28. |