| Description | Saperconazole is a broad-spectrum antifungal triazole (MIC90: 0.19 mg/L). |
| In vitro | The antifungal activity of Saperconazole is complete at 1 μg/mL. 80% of all strains show a complete absence of growth at 0.1 μg/mL (85% for A. fumigatus), and this result persists during 14 days of the test[2]. |
| In vivo | Saperconazole (2.5 mg/kg) administered, is not active, but when it is given at 5 or 10 mg/kg, 92 or 100%, respectively, survive and organ cultures are negative.[2]. |
| Synonyms | 沙康唑, R66905 |
| molecular weight | 672.72 |
| Molecular formula | C35H38F2N8O4 |
| CAS | 110588-57-3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| References | 1. Otcenásek M, et al. Susceptibility of clinical isolates of fungi to saperconazole. Mycopathologia. 1992 Jun;118(3):179-83. 2. VVan Cutsem J, et al. Oral and parenteral therapy with saperconazole (R 66905) of invasive aspergillosis in normal and immunocompromised animals. Antimicrob Agents Chemother. 1989 Dec;33(12):2063-8. |