| Description | Levalbuterol, also known as (R)-Albuterol or (R)-Salbutamol, is the active (R)-enantiomer of Salbutamol and serves as a short-acting β2-adrenergic receptor agonist. It is a more potent bronchodilator than Salbutamol and holds promise for the treatment of Chronic Obstructive Pulmonary Disease (COPD). |
| In vitro | Levalbuterol (10 μM; 24 hours) induces 11β-HSD1 mRNA expression, however, it does not influence 11β-HSD2 expression in airway epithelial cells[1].Levalbuterol (10 μM; 24 hours) significantly reduces both LPS- and TNF-α-induced NF-κB activity while increasing GRE activation in an 11β-HSD1 dependent manner in a transformed mouse airway epithelial cell line[1]. RT-PCR[1]Cell Line: Murine Club (MTCC) cells Concentration: 10 μM Incubation Time: 24 hours Result: Increased 11β-HSD1 mRNA expression selectively. |
| In vivo | Levalbuterol (subcutaneous injection; 1 mg/kg; 14 days) significantly decreases pulmonary inflammation in OVA mice, demonstrated a decrease in eosinophilia and IgE[3]. Animal Model: C57BL/6 female mice?with a pulmonary allergic model[3]Dosage: 1 mg/kg Administration: Subcutaneous injection; 1 mg/kg; 14 days Result: Decreased pulmonary inflammation after OVA sensitization. |
| Synonyms | (R)-Albuterol, 左沙丁胺醇, Levosalbutamol, (R)-Salbutamol |
| molecular weight | 239.31 |
| Molecular formula | C13H21NO3 |
| CAS | 34391-04-3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Randall MJ, et al. Anti-inflammatory effects of levalbuterol-induced 11β-hydroxysteroid dehydrogenase type 1 activity in airway epithelial cells.Front Endocrinol (Lausanne). 2015 Jan 12;5:236. 2. Ferrada MA, et al. (R)-albuterol decreases immune responses: role of activated T cells.Respir Res. 2008 Jan 14;9:3. |