| Description | Salcaprozate sodium (SNAC), an oral absorption promoter, serves as a potent delivery agent for oral heparin and insulin by enhancing passive transcellular permeation through small intestinal epithelia. This is achieved through its capability to increase lipophilicity via non-covalent macromolecule complexation. |
| In vitro | Salcaprozate sodium（SNAC；12.5-400 μg/mL；24小时）对Caco-2细胞无毒性，并且当SNAC浓度为200 μg/mL时，存活率超过90%。SNAC（50和200 μg/mL）比SAs溶液的Papp提高了RA和SA-B的表观通透系数（Papp）2.14倍和3.68倍[1]。 |
| Synonyms | 8-(2-羟基苯甲酰胺基)辛酸钠, SNAC |
| molecular weight | 301.32 |
| Molecular formula | C15H20NNaO4 |
| CAS | 203787-91-1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 100 mg/mL (331.88 mM), Sonication is recommended. |
| References | 1. Li Y, et, al. Impact of Sodium N-[8-(2-Hydroxybenzoyl)amino]-caprylate on Intestinal Permeability for Notoginsenoside R1 and Salvianolic Acids in Caco-2 Cells Transport and Rat Pharmacokinetics. Molecules. 2018 Nov 16; 23(11):2990. 2. Twarog C, et, al. Intestinal Permeation Enhancers for Oral Delivery of Macromolecules: A Comparison between Salcaprozate Sodium (SNAC) and Sodium Caprate (C 10). Pharmaceutics. 2019 Feb 13; 11(2):78. |