| Description | FPR A14 is an agonist of formyl peptide receptor (FPR) and induces cell differentiation. |
| In vitro | FPR A14 在促进中性粒细胞Ca2+释放和化学趋化物方面表现出活性，其半最大有效浓度（EC50s）分别为630 nM和42 nM[1]。在小鼠神经母细胞瘤N2a细胞中，FPR A14（10 μM）能够使细胞分化增加93.3%[2]。 |
| Target activity | Ca2+ chemoattractant:42 nM, Ca2+ release:630 nM |
| molecular weight | 404.42 |
| Molecular formula | C23H20N2O5 |
| CAS | 329691-12-5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 45 mg/mL (111.27 mM), Sonication is recommended. |
| References | 1. Igor A Schepetkin, et al. High-throughput screening for small-molecule activators of neutrophils: identification of novel N-formyl peptide receptor agonists. Mol Pharmacol. 2007 Apr;71(4):1061-74. 2. Peter J G Cussell, et al. The formyl peptide receptor agonist FPRa14 induces differentiation of Neuro2a mouse neuroblastoma cells into multiple distinct morphologies which can be specifically. inhibited with FPR antagonists and FPR knockdown using siRNA. PLoS One. 2019 Jun 6;14(6):e0217815. |