| Description | Safingol hydrochloride (L-threo-dihydrosphingosine hydrochloride) is a specific inhibitor of protein kinase C. It induces autophagy in solid tumor cells and cancer cell death by inhibiting the PKC and PI3-kinase pathways.BIIB 722 Mesylate is a selective sodium-hydrogen exchange inhibitor. Safingol hydrochloride inhibits PKC and PI3k. |
| Synonyms | SPC 100270 hydrochloride, L-threo-dihydrosphingosine hydrochloride |
| molecular weight | 337.969 |
| Molecular formula | C18H40ClNO2 |
| CAS | 139755-79-6 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Tan KB,et al. In vivo efficacy of a novel liposomal formulation of safingol in the treatment of acute myeloid leukemia. J Control Release. 2012 Jun 10;160(2):290-8. |