| Description | S26131 (N-[2-[7-[3-[8-(2-acetamidoethyl)naphthalen-2-yl]oxypropoxy]naphthalen-1-yl]ethyl]acetamide) behaves as an antagonist on MT1 and MT2 receptors with Ki of 0.5 and 112 nM respectively. |
| In vitro | S26131是一种有效且选择性的MT1和MT2拮抗剂，其KB值分别为5.32 nM和143 nM[1]。 |
| Target activity | MT1:0.5 nM(Ki), MT2:112 nM(Ki) |
| Synonyms | N-[2-[7-[3-[8-(2-acetamidoethyl)naphthalen-2-yl]oxypropoxy]naphthalen-1-yl]ethyl]acetamide |
| molecular weight | 498.61 |
| Molecular formula | C31H34N2O4 |
| CAS | 296280-56-3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 25 mg/mL (50.14 mM), Sonication is recommended. |
| References | 1. Descamps-François C, et al. Design and synthesis of naphthalenic dimers as selective MT1 melatoninergic ligands. J Med Chem. 2003 Mar 27;46(7):1127-9. |