| Description | S18-000003 is an effective orally bioavailable retinoic acid receptor-related orphan receptor-gamma-t inhibitor (IC50: 29 nM). S18-000003 inhibits IL-17 production. |
| Target activity | RORγt:29 nM |
| molecular weight | 518.55 |
| Molecular formula | C26H25F3N2O4S |
| CAS | 2068119-11-7 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 100 mg/mL (192.85 mM), Sonication is recommended. |
| References | 1. Sasaki Y, et al. Discovery of a potent orally bioavailable retinoic acid receptor-related orphan receptor-gamma-t (RORγt) inhibitor, S18-000003. Bioorg Med Chem Lett. 2018 Dec 1;28(22):3549-3553. |