| Description | RN-18 antagonizes Vif function and inhibits HIV-1 replication only in the presence of A3G. RN-18 increases cellular A3G levels in a Vif-dependent manner and increases A3G incorporation into virions without inhibiting general proteasome-mediated protein degradation. RN-18 enhances Vif degradation only in the presence of A3G, reduces viral infectivity by increasing A3G incorporation into virions and enhances cytidine deamination of the viral genome. |
| In vitro | S119-8 是 S119 的类似物，具有广泛的食物活性，抑制乙型流感病毒和奥司他韦耐药的甲型流感病毒的活性，但不抑制非流感病毒水疱性口炎病毒 (VSV)。 S119-8 通过 IC 抑制流感病毒 A/Puerto Rico/8/1934 (H1N1) (PR8)506.05μM。 S119-8 通过 IC 抑制甲型流感/越南/1203/2004 (H5N1)508.42μM[1]。 |
| molecular weight | 344.45 |
| Molecular formula | C23H24N2O |
| CAS | 443639-96-1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 55 mg/mL (159.67 mM) |
| References | 1. White KM, et al. Broad Spectrum Inhibitor of Influenza A and B Viruses Targeting the Viral Nucleoprotein. ACS Infect Dis. 2018 Feb 9;4(2):146-157. |