| Description | PP7 is a potent inhibitor of PB1-PB2 interaction(IC50 of 8.6 μM). |
| In vitro | PP7 对病毒聚合酶活性展现了抑制作用（IC50=9.5 μM）。此外，PP7 显示出对细胞培养中流感病毒亚型 A (H1N1)pdm09(EC50=1.4 μM)、A(H7N9) 和 A(H9N2) 的抗病毒活性[1]。 |
| Target activity | PB1-PB2:8.6 μM , Viral polymerase activity:9.5 μM, Influenza virus subtypes A (H1N1) pdm09:1.4 μM(EC50) |
| molecular weight | 377.22 |
| Molecular formula | C18H14Cl2N2O3 |
| CAS | 433238-84-7 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 1 mg/mL (2.65 mM), Sonication is recommended. |
| References | 1. Yuan S, et al. Identification of a novel small-molecule compound targeting the influenza A virus polymerase PB1-PB2 interface. Antiviral Res. 2017 Jan;137:58-66. |