| Description | RO5203648 HCl is a partial agonist of trace amine-related receptor 1 (TAAR1) with antipsychotic and antidepressant-like activities. RO5203648 HCl can be used in studies about neuropsychiatric therapeutics. |
| Synonyms | RO5203648, RO-5203648, RO 5203648 |
| molecular weight | 231.08 |
| Molecular formula | C9H8Cl2N2O |
| CAS | 1043491-54-8 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 4.4 mg/mL (19.04 mM) |
| References | 1. Pei Y, et al. Selective activation of the trace amine-associated receptor 1 decreases cocaine's reinforcing efficacy and prevents cocaine-induced changes in brain reward thresholds. Prog Neuropsychopharmacol Biol Psychiatry. 2015 Dec 3;63:70-5. 2. Cotter R, et al. The trace amine-associated receptor 1 modulates methamphetamine's neurochemical and behavioral effects. Front Neurosci. 2015 Feb 13;9:39. 3. Pei Y, et al. Activation of the trace amine-associated receptor 1 prevents relapse to cocaine seeking. Neuropsychopharmacology. 2014 Sep;39(10):2299-308. 4. Revel FG, et al. Trace amine-associated receptor 1 partial agonism reveals novel paradigm for neuropsychiatric therapeutics. Biol Psychiatry. 2012 Dec 1;72(11):934-42. |