| Description | 5-fluoro 203 (NSC-703786) is a cytotoxic molecule leading to cell death by forming DNA adducts. 5-fluoro 203 induces aryl hydrocarbon receptor signaling, and elevates expression of CYP1A1. 5-fluoro 203 treatment of cells also leads to elevation of reactive oxygen species and activation of p38, JNK and ERK. |
| In vitro | 雌激素受体阳性(ER+; MCF-7和T47D)乳腺癌细胞、雌激素受体阴性(ER-; CRL2335、MDA-MB-231和MDA-MB-468)乳腺癌细胞，以及非恶性MCF-10A细胞被用5F 203或载体对照(0.1% DMSO)处理72小时。非恶性MCF-10A乳腺上皮细胞和MDA-MB-231乳腺癌细胞对5F 203治疗表现出耐药性，而其他细胞系对5F 203的敏感性各不相同。 |
| Synonyms | 5F-203, NSC-703786 |
| molecular weight | 258.31 |
| Molecular formula | C14H11FN2S |
| CAS | 260443-89-8 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 25 mg/mL (96.78 mM) |
| References | 1. Mclean L S , Watkins C N , Campbell P , et al. Aryl Hydrocarbon Receptor Ligand 5F 203 Induces Oxidative Stress That Triggers DNA Damage in Human Breast Cancer Cells[J]. Chemical Research in Toxicology, 2015, 28(5):855-71. |