| Description | RIPK3-IN-3 (compound 20) is a selective RIPK3 inhibitor that demonstrates potent activity with an IC50 value of 10 nM. This compound effectively blocks RIPK3-mediated phosphorylation of MLKL, preventing its oligomerization and subsequent induction of necroptosis. Additionally, RIPK3-IN-3 suppresses CXCL5 secretion and impedes AsPC-1 cell migration and invasion [1]. |
| molecular weight | 305.36 |
| Molecular formula | C16H11N5S |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |