| Description | Retro-2 cycl is an antiviral agent and a selective inhibitor of retrograde protein trafficking mediated by syntaxin-5 at the interface. Retro-2 cycl inhibits JCPyV(IC50s: 54 μM) and HPV16 pseudovirus(IC50s: 160 μM). |
| Target activity | JCPyV:54 μM, HPV-16:160 μM |
| Synonyms | RN 1-001 |
| molecular weight | 320.41 |
| Molecular formula | C19H16N2OS |
| CAS | 1429192-00-6 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | H2O: < 0.1 mg/mL (insoluble) DMSO: 45 mg/mL (140.45 mM) |
| References | 1. Carney DW, et al. Structural optimization of a retrograde trafficking inhibitor that protects cells from infections by human polyoma- and papillomaviruses. Bioorg Med Chem. 2014 Sep 1;22(17):4836-47. |