| Description | MRK-560 is an effective and brain-penetrant inhibitor of γ-secretase. |
| molecular weight | 517.92 |
| Molecular formula | C19H17ClF5NO4S2 |
| CAS | 677772-84-8 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 60 mg/ml (115.85 mM), Sonication is recommended. |
| References | 1. Best JD, et al. The novel gamma secretase inhibitor N-[cis-4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexyl]-1,1,1-trifluoromethanesulfonamide (MRK-560) reduces amyloid plaque deposition without evidence of notch-related pathology in the Tg2576 mouse. J Pharmacol Exp Ther. 2007 Feb;320(2):552-8. |