| Description | RET-IN-22 (compound 17b) is a potent, selective, and orally active inhibitor of RET, exhibiting IC50 values of 20.9 nM for wild-type RET and 18.3 nM for RET-V804M. It demonstrates a highly selective inhibition profile across a broad spectrum of kinases, with notable specificity over EGFR and VEGFR2. Additionally, RET-IN-22 is implicated in exerting anticancer effects [1]. |
| molecular weight | 584.59 |
| Molecular formula | C29H31F3N6O4 |
| CAS | 2918281-79-3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |