| Description | AChE/BuChE/MAO-B-IN-2 (compound 4b) is a potent inhibitor of AChE, BuChE, and hu MAO-B, with respective IC50 values of 5.3 μM, 12.4 μM, and 1.9±0.08 μM, indicating good in vitro blood-brain barrier (BBB) permeability. It is effective in reducing excessive AChE and BuChE levels associated with Alzheimer's disease (AD) and holds potential for use in anti-Alzheimer's research [1]. |
| In vitro | AChE/BuChE/MAO-B-IN-2（化合物4b）（5、10、20 μmol/L，2小时）对Aβ1-42诱导的PC12细胞损伤有显著神经保护效果[1]。同一化合物（1 mg/mL，孵育0、0.5、1、1.5、2、3小时）在模拟胃肠液、血浆及大鼠肝微粒体环境中显示出良好稳定性[1]。 |
| In vivo | AChE/BuChE/MAO-B-IN-2（化合物4b）（处理10分钟后浓度分别为0.0049、0.0195及0.078 μg/mL）能有效改善ACAL 3 致的斑马鱼AD模型的运动功能障碍和反应能力[1]。 |
| Target activity | AChE:5.3 μM, BChE:12.4 μM, MAO-B (human):1.9 μM |
| molecular weight | 327.35 |
| Molecular formula | C19H18FNO3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |