| Description | 1. Resibufogenin (Bufogenin) is a cytotoxic steroid isolated from the Chinese drug ChanSu. 2. Resibufogenin can inhibit rectifier potassium current ( I K ) and transient potassium current ( I A ), it has pathological effects on central nervous system. 3. Resibufogenin corrects hypertension in a rat model of human preeclampsia, it not only prevents the advent of hypertension and proteinuria, but also the development of intrauterine growth restriction.4. Resibufogenina's major metabolic pathway in the human liver is CYP3A4 dominantly mediated 5β-hydroxylation . |
| Synonyms | 酯蟾毒配基, Bufogenin, Recibufogenin, 酯蟾毒配基，蟾力苏 |
| molecular weight | 384.51 |
| Molecular formula | C24H32O4 |
| CAS | 465-39-4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 55 mg/mL (143.04 mM) |
| References | 1. Horvat D , Severson J , Uddin M N , et al. Resibufogenin Prevents the Manifestations of Preeclampsia in an Animal Model of the Syndrome[J]. Hypertension in Pregnancy, 2010, 29(1):1-9. |