| Description | Reproxalap (NS-2) covalently binds aldehydes including malondialdehyde and 4-hydroxynonenal. Reproxalap is a reactive aldehyde species sequestering agent for the treatment of the dry eye. |
| Synonyms | NS-2, ADX-102 |
| molecular weight | 236.7 |
| Molecular formula | C12H13ClN2O |
| CAS | 916056-79-6 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 55 mg/mL (232.36 mM) |
| References | 1. Susan Macdonald, et al. ADX-102, a novel aldehyde trap, reduces nociceptive behavior in mouse models of carrageenan and CFA induced pain. 2. Reproxalap Phase 2b Dry Eye Disease Results. |
| Citations | 1. Ochoa C A, Nissen C G, Mosley D D, et al. Aldehyde Trapping by ADX-102 Is Protective against Cigarette Smoke and Alcohol Mediated Lung Cell Injury. Biomolecules. 2022, 12(3): 393. |