| Description | MeAIB is an N-acetyltransferase inhibitor that inhibits SNAT2-related signaling pathways. MeAIB is a specific substrate for amino acid transport system a (ATA1). Amino acid transport system a (ATA1) regulates the uptake of short chain neutral amino acids by Na+ flow. |
| In vitro | ATA3是一种新型的氨基酸转运系统A的亚型，主要表达在肝脏和骨骼肌中。ATA1（亦称为GlnT）和ATA2（亦称为SAT2）已从大鼠和人体组织中克隆出来。这些转运蛋白以Na+依赖的方式控制着短链中性氨基酸的摄入[1]。 |
| Synonyms | α-(Methylamino)isobutyric acid |
| molecular weight | 117.15 |
| Molecular formula | C5H11NO2 |
| CAS | 2566-34-9 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 45.0 mg/mL (384.1 mM), when pH is adjusted to 2 with 1M HCl. Sonication and heating to 60℃ are recommended. H2O: 90.0 mg/mL (768.2 mM), Sonication is recommended. |
| References | 1. M Sugawara, et al. Structure and function of ATA3, a new subtype of amino acid transport system A, primarily expressed in the liver and skeletal muscle. Biochim Biophys Acta. 2000 Dec 20;1509(1-2):7-13. 2. Y Kudo, et al. Changes in expression and function of syncytin and its receptor, amino acid transport system B(0) (ASCT2), in human placental choriocarcinoma BeWo cells during syncytialization. Placenta. 2002 Aug;23(7):536-41. |