| Description | Pyrazolo[1,5-a]pyrimidine 4h is a morpholine derivative that is a selective antagonist of the adenosine A2A receptor. It has been shown to be neuroprotective in animal models of Parkinson's disease and Huntington's chorea. |
| In vivo | 仅有Parthenolide这种具有抗炎特性的HDAC抑制剂，在Phb1 KO肝细胞中展现了强大的抗凋亡效果。实际上，经TSA和Parthenolide处理的肝细胞显示FXR水平上升，而CYP7A1、HDAC4、TNFα、TRAIL和Bax的水平降低，暗示了由于特定HDAC抑制作用，胆汁酸的毒性效果减少，从而减轻了Phb1 KO肝细胞的凋亡反应。重要的是，Parthenolide在Phb1 KO小鼠BDL后对肝损伤具有保护作用。实际上，Parthenolide处理导致这些小鼠在BDL后的死亡率降低，与较低的凋亡反应相关，如通过减少坏死区域、Tunel染色以及ALT（8431±957 vs. 4225±210 U/L）和AST（4805±300 vs. 2242±438 U/L）活性的降低与对照的Phb1 KO小鼠相比所揭示的[3]。 |
| molecular weight | 401.46 |
| Molecular formula | C23H23N5O2 |
| CAS | 597544-21-3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 25 mg/mL (62.27 mM), Sonication is recommended. |
| References | 1. Zhang, J., Peng, JF., Bai, YB. et al. Mol Divers (2016) 20: 887. https://doi.org/10.1007/s11030-016-9690-y |