| Description | Handle region peptide, rat acetate is a prorenin receptor antagonist, suppresses the progression of diabetic nephropathy and has anti-inflammatory in the eye. |
| In vitro | Handle region peptide, rat是一种（pro）renin受体拮抗剂。在浓度为1 μM时，能够降低活跃ERK1/2与总ERK1/2的比例。在0.1-1 μM浓度范围内，能减少TGF-β1 mRNA水平并以剂量依赖性方式抑制系膜细胞增殖。此外，在0.01-1 μM范围内，Handle region peptide, rat可增加MMP-2活性[1]。 |
| In vivo | Handle region peptide, rat acetate (0.1 mg/kg)在内毒素诱导的葡萄膜炎(EIU)视网膜中抑制白细胞黏附，并减少大鼠的白细胞计数。处理区域肽，大鼠(0.1 mg/kg)降低由LPS诱导的EIU大鼠的蛋白浓度，并减少炎症介质如ICAM-1、CCL2/MCP-1和IL-6在大鼠中的mRNA表达和蛋白水平[2]。 |
| Synonyms | Handle region peptide, rat acetate(749227-53-0 free base) |
| molecular weight | 1244.61 |
| Molecular formula | C56H105N15O14S |
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: Insoluble H2O: 10 mM |
| References | 1. He M, et al. Inhibition of renin/prorenin receptor attenuated mesangial cell proliferation and reduced associated fibrotic factor release. Eur J Pharmacol. 2009 Mar 15;606(1-3):155-61. |