PXS-4728A Bioactivity,Chemical Properties,Storage & Solubility Information Pathways-PeptideDB

Description	BI-1467335 HCl(BI 1467335) is a selective, orally active inhibitor of semicarbazide-sensitive amine oxidase (SSAO) that helps improve chronic obstructive pulmonary disease in mice[2].
Synonyms	BI-1467335, BI 1467335, BI1467335, BI-1467335 HCl
molecular weight	316.8
Molecular formula	C15H22ClFN2O2
CAS	1478364-68-9
Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year
Solubility	H2O: 100 mg/mL (315.66 mM) DMSO: 220 mg/mL (694.44 mM)
References	1. Schilter HC, Collison A, Russo RC, Foot JS, Yow TT, Vieira AT, Tavares LD, Mattes J, Teixeira MM, Jarolimek W. Effects of an anti-inflammatory VAP-1/SSAO inhibitor, PXS-4728A, on pulmonary neutrophil migration. Respir Res. 2015 Mar 20;16:42. 2. Jarnicki AG, Schilter H, Liu G, Wheeldon K, Essilfie AT, Foot JS, Yow TT, Jarolimek W, Hansbro PM. The inhibitor of semicarbazide-sensitive amine oxidase, PXS-4728A, ameliorates key features of chronic obstructive pulmonary disease in a mouse model. Br J Pharmacol. 2016 Nov;173(22):3161-3175. 3. Katagiri D, Hamasaki Y, Doi K, Negishi K, Sugaya T, Nangaku M, Noiri E. Interstitial renal fibrosis due to multiple cisplatin treatments is ameliorated by semicarbazide-sensitive amine oxidase inhibition. Kidney Int. 2016 Feb;89(2):374-85.

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