| Description | PTP Inhibitor IV is an effective protein tyrosine phosphatase (PTP) inhibitor, which can selectively inhibit DUSP14 phosphatase activity (IC50.5.21μm). PTP Inhibitor IV inhibited SHP-2, PTP1B, PTp-ε, PTP Meg-2, PTP-σ, PTP-β and PTP-μ, IC50 were 1.8 μM, 2.5 μM, 8.4 μM, 13 μM, 20 μM, 6.4 μM, and 6.7 μM, respectively. PTP Inhibitor IV affects cellular signaling by inhibiting PTP activity and may regulate specific pathways associated with PTP-mediated signaling events. |
| In vitro | PTP Inhibitor IV通过结合于DUSP14的催化位点，降低了其催化活性。[1] 在0-100 μM浓度和3小时的处理时间内，PTP Inhibitor IV能够有效且特异性地抑制DUSP14介导的JNK去磷酸化作用。[1] |
| Target activity | PTP Meg2:13 μM, PTP-ε:8.4 μM, DUSP14:5.21 μM, PTP-σ:20 μM, PTP1B:2.5 μM, SHP2:1.8 μM, PTP-μ:6.7 μM, PTP-β:6.4 μM |
| molecular weight | 608.62 |
| Molecular formula | C26H26F6N2O4S2 |
| CAS | 329317-98-8 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 225.0 mg/mL (369.7 mM), Sonication is recommended. |
| References | 1. Park JE, et al. PTP inhibitor IV protects JNK kinase activity by inhibiting dual-specificity phosphatase 14 (DUSP14). Biochem Biophys Res Commun. 2009;387(4):795-799. 2. Huang P, et al. Structure-based design and discovery of novel inhibitors of protein tyrosine phosphatases. Bioorg Med Chem. 2003;11(8):1835-1849. |