| Description | Halofenozide is an ecdysteroid agonist and used as a pesticide. |
| In vivo | 在科罗拉多马铃薯甲虫(CPB)中，产品的极其缓慢排泄表明，这一事实必定是halofenozide在最高剂量20μg/成虫时对繁殖力持久作用的重要因素。在AMF和CPB的雄性生殖系统中，halofenozide的保留量低，而在雌性（卵巢+卵子）中回收到的放射性水平高[1]。2000年季节，在初级繁殖个体上局部应用0.1μl DMSO中的5μg非甾体类蜕皮激素拮抗剂RH-0345（halofenozide）显着减少了产卵数量。然而，经过治疗的雌性在2001年完全恢复。2001年尝试了局部应用和饲喂两种方法。显著效果仅在局部治疗组观察到，这或许是由于饲喂的不一致性。在此组中，总后代、卵巢中卵泡的数量以及雌性个体的大颚腺（CA）大小均显著减少[2]。 |
| molecular weight | 330.81 |
| Molecular formula | C18H19ClN2O2 |
| CAS | 112226-61-6 |
| Storage | |Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 30 mg/mL (90.69 mM) |
| References | 1. Farin s GP, et al. Action and pharmacokinetics of a novel insect growth regulator, halofenozide, in adult beetles of aubeonymus mariaefranciscae and leptinotarsa decemlineata. Arch Insect Biochem Physiol. 1999;41(4):201-13. 2. Raina AK, et al. Ecdysone agonist halofenozide affects corpora allata and reproductive physiology of the Formosan subterranean termite, Coptotermes formosanus. J Insect Physiol. 2003 Jul;49(7):677-83. 3. Li Y, Sun H, Tian Z, et al. The determination of Plutella xylostella (L.) GSTs (PxGSTs) involved in the detoxification metabolism of Tolfenpyrad[J]. Pest Management Science. 2020. |
| Citations | 1. Li Y, Sun H, Tian Z, et al. The determination of Plutella xylostella (L.) GSTs (PxGSTs) involved in the detoxification metabolism of Tolfenpyrad. Pest Management Science. 2020 |