| Description | PTP inhibitor 1 is an inhibitor of cell-permeable protein tyrosine phosphatase (PTP) that covalently binds the catalytic domain of the Src homology region 2 domain-containing phosphatase (SHP-1(ΔSH2)),with Ki of128 μM. |
| Target activity | SHP1 (ΔSH2, cell-free assay):128 μM(Ki) |
| Synonyms | PTP Inhibitor II, alpha-溴-4-甲氧基苯乙酮 |
| molecular weight | 229.07 |
| Molecular formula | C9H9BrO2 |
| CAS | 2632-13-5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 55 mg/mL (240.1 mM), Sonication is recommended. |
| References | 1. Arabaci G , Guo X C , Beebe K D , et al. α-Haloacetophenone Derivatives As Photoreversible Covalent Inhibitors of Protein Tyrosine Phosphatases[J]. Journal of the American Chemical Society, 1999, 121(21):5085-5086. |