| Description | M2N12 is a potent and highly selective inhibitor of cell division cycle 25C protein phosphatase (Cdc25C, IC50 = 0.09 μM). M2N12 has anti-tumor activity. M2N12 also has promising activity against Cdc25A(IC50 = 0.53 μM) and Cdc25B(IC50 = 1.39 μM). |
| In vitro | M2N12 对五种肿瘤细胞系及一种正常细胞系表现出细胞毒性活性，涉及的细胞系包括A-549（IC50 = 3.92 μM）、MDA-MB-231（IC50 = 4.63 μM）、KB（IC50 = 5.05 μM）、KB-VIN（IC50 = 6.81 μM）、MCF-7（IC50 = 4.71 μM）和HBE（IC50 = 6.00 μM）[1]。 |
| Target activity | KB-VIN:6.81 μM, CDC25C:0.09 μM, MCF-7 cells:4.71 μM, A549 cells:3.92 μM, MDA-MB-231 cells:4.63 μM, HBE:6.00 μM, KB:5.05 μM |
| molecular weight | 393.83 |
| Molecular formula | C20H16ClN5O2 |
| CAS | 2376577-06-7 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 8 mg/mL (20.31 mM) |
| References | 1. Jing L, et al. Identification of highly potent and selective Cdc25 protein phosphatases inhibitors from miniaturization click-chemistry-based combinatorial libraries. Eur J Med Chem. 2019 Sep 14;183:111696. |