| Description | Propargyl-PEG1-acrylate is a polyethylene glycol (PEG) derived linker employed in the synthesis of proteolysis-targeting chimeras (PROTACs)[1]. |
| In vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
| molecular weight | 154.16 |
| Molecular formula | C8H10O3 |
| CAS | 52436-42-7 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| References | 1. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |