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Propagermanium

CAS No.: 12758-40-6

Propagermanium (Ge132), an organometallic compound of germanium, has been used as a therapeutic agent against chronic he
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Description Propagermanium (Ge132), an organometallic compound of germanium, has been used as a therapeutic agent against chronic hepatitis B in Japan.
Synonyms Dipropanoic acid germanium sequioxide, SK-818, Ge 132, 二羧乙基三氧化二锗, Ge132, SK 818, Ge-132
molecular weight 339.42
Molecular formula C6H10Ge2O7
CAS 12758-40-6
Storage Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility DMSO: Slightly soluble
References 1. Mizuno N, Nishibori E, Oka M, Jomori T, Takata M, Kumasaka T. Structural Basis for Polymer Packing and Solvation Properties of the Organogermanium Crystalline Polymer Propagermanium and Its Derivatives. J Pharm Sci. 2015 Aug;104(8):2482-8. doi: 10.1002/jps.24486. Epub 2015 Jun 2. PubMed PMID: 26037234. 2. Tamura Y, Sugimoto M, Murayama T, Minami M, Nishikaze Y, Ariyasu H, Akamizu T, Kita T, Yokode M, Arai H. C-C chemokine receptor 2 inhibitor improves diet-induced development of insulin resistance and hepatic steatosis in mice. J Atheroscler Thromb. 2010 Mar 31;17(3):219-28. Epub 2010 Feb 24. PubMed PMID: 20179360. 3. Tsukuda K, Mogi M, Iwanami J, Min LJ, Jing F, Oshima K, Horiuchi M. Irbesartan attenuates ischemic brain damage by inhibition of MCP-1/CCR2 signaling pathway beyond AT₁ receptor blockade. Biochem Biophys Res Commun. 2011 Jun 3;409(2):275-9. doi: 10.1016/j.bbrc.2011.04.142. Epub 2011 May 14. PubMed PMID: 21575596. 4. Tsutsumi Y, Tanaka J, Kanamori H, Musashi M, Minami H, Fukushima A, Yamato H, Ehira N, Kawamura T, Obara S, Ogura N, Asaka M, Imamura M, Masauzi N. Effectiveness of propagermanium treatment in multiple myeloma patients. Eur J Haematol. 2004 Dec;73(6):397-401. PubMed PMID: 15522060.