| Description | Prednicarbate (Hoe 777) is a Corticosteroid Hormone Receptor Agonist. Prednicarbate has antipruritic, anti-inflammatory, and vasoconstrictive properties. It also decreases the number of circulating lymphocytes by inhibiting the production of vasodilators such as nitric oxide and prostacyclin. |
| Synonyms | Hoe 777, Hoe-777, Dermatop E emollient, UNII-V901LV1K7D |
| molecular weight | 488.57 |
| Molecular formula | C27H36O8 |
| CAS | 73771-04-7 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | H2O: Insoluble DMSO: 10 mg/mL (20.47 mM), Sonication is recommended. |
| References | 1. Otero-Rivas MM, Ruiz-González I, Pérez-Bustillo A, Rodríguez-Prieto MÁ. Allergic contact dermatitis caused by prednicarbate presenting as chronic hand eczema. Contact Dermatitis. 2015 Jul;73(1):51-2. 2. Bätz FM, et al. Esterase activity in excised and reconstructed human skin--biotransformation of prednicarbate and the model dye fluorescein diacetate. Eur J Pharm Biopharm. 2013 Jun;84(2):374-85. 3. Katzer K, et al. Topical therapy with nadifloxacin cream and prednicarbate cream improves acneiform eruptions caused by the EGFR-inhibitor cetuximab - A report of 29 patients. Eur J Dermatol. 2010 Jan-Feb;20(1):82-4. 4. Baspinar Y, Keck CM, Borchert HH. Development of a positively charged prednicarbate nanoemulsion. Int J Pharm. 2010 Jan 4;383(1-2):201-8. |