| Description | DCZ3301 is a novel aryl-guanidino inhibitor. |
| In vitro | DCZ3301处理以时间和剂量依赖的方式显著抑制了Jurkat和HUT78细胞，分别在48小时治疗后，Jurkat和HUT78细胞的IC50值为3.02μM和9.42μM。 |
| Synonyms | NPS ALX Compound 4a hydrochloride(1:1)(299433-10-6 Free base) |
| molecular weight | 464.83 |
| Molecular formula | C20H16ClF3N6O2 |
| CAS | 2136278-38-9 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 50 mg/mL (107.57 mM) |
| References | 1. Xiao W, et al. DCZ3301, a novel aryl-guanidino inhibitor, induces cell apoptosis and cell cycle arrest via suppressing the PI3K/AKT pathway in T-cell leukemia/lymphoma. Acta Biochim Biophys Sin (Shanghai). 2018 Jul 1;50(7):643-650. |