| Description | Pramlintide acetate is a polypeptide analogue of human amylin. It serves as an antidiabetic agent and exhibits antineoplastic activity in colorectal cancer. |
| In vitro | Pramlintide以剂量依赖性抑制了HCT-116和HT-29的生长，其对后者的抑制效果更高（IC50s；分别为48.67和9.10 μg/mL；p值=0.013）。此外，将5、10和20 μg/mL的Pramlintide与5-氟尿嘧啶、奥沙利铂或伊立替康合用于HCT-116和HT-29时，可协同增强抗增殖效应（R>1.6，p值<0.05）。 |
| molecular weight | 4009 |
| Molecular formula | C173H271N51O55S2 |
| CAS | 187887-46-3 |
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 10 mM |
| References | 1. Maha S Al-Keilani, et al. Pramlintide, an antidiabetic, is antineoplastic in colorectal cancer and synergizes with conventional chemotherapy. Clin Pharmacol. 2018 Mar 5;10:23-29. |
Pramlintide acetate(151126-32-8 free base)
CAS No.: 187887-46-3
Pramlintide acetate is a polypeptide analogue of human amylin. It serves as an antidiabetic agent and exhibits antineopl
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