| Description | PQM130 is a Feruloyl-Donepezil Hybrid compound against the neurotoxicity induced by Aβ1-42 oligomer (AβO) and shows anti-inflammatory activity. PQM130 can be used in anti-AD studies. |
| In vitro | PQM130已在多个体内模型中表现出抗炎活性，并在人类神经细胞中显示出神经保护活性。 |
| In vivo | 小鼠脑室内注射AβO引起记忆障碍、氧化应激、神经退行性变和神经炎症的增加。相反，AβO注射后，PQM130 (0.5-1 mg/kg)治疗减轻了氧化损伤和神经炎症，通过调节糖原合酶激酶3β (GSK3β) 和细胞外信号调节激酶 (ERK1/2) 促进了细胞存活和蛋白合成。此外，PQM130提高了大脑可塑性，并保护小鼠免受空间认知能力下降的影响。PQM130调节的途径与多奈哌齐不同，并且在抵抗AβO损伤方面效果更显著。 |
| molecular weight | 381.46 |
| Molecular formula | C23H27NO4 |
| CAS | 2089415-51-8 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 5.5 mg/mL (14.42 mM) |
| References | 1. Morroni F, et al. PQM130, a Novel Feruloyl-Donepezil Hybrid Compound, Effectively Ameliorates the Cognitive Impairments and Pathology in a Mouse Model of Alzheimer's Disease. Front Pharmacol. 2019 Jun 12;10:658. |