Pentosan Polysulfate Sodium (W/W 43%) Bioactivity,Chemical Properties,Storage & Solubility Information Pathways-PeptideDB

Description	Pentosan Polysulfate Sodium is a potent and selective anti-HIV agent.with anti-inflammatory and pro-chondrogenic properties,and used for treatment of interstitial cystitis.
In vitro	Pentosan Polysulfate Sodium suppresses NF-κB, decreases the proinflammatory actions of TNFα, and decreases high glucose and advanced glycation end products (AGEs) stimulated MCP-1 production[3].
In vivo	Pentosan Polysulfate Sodium treatment preserves renal function, significantly reduces albuminuria, and markedly decreases the severity of renal lesions, including tubulointerstitial inflammation. Pentosan Polysulfate Sodium also reduces upregulation of TNFα and proinflammatory genes in aging diabetic kidneys[3].
Synonyms	Pentosan Polysulfate Sodium
molecular weight	N/A
CAS	140207-93-8
Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year
References	1. Schuchman EH, et al. Pentosan polysulfate: a novel therapy for the mucopolysaccharidoses. PLoS One. 2013;8(1):e54459. 2. Baba M, et al. Pentosan polysulfate, a sulfated oligosaccharide, is a potent and selective anti-HIV agent in vitro. Antiviral Res. 1988 Sep;9(6):335-43. 3. Wu J, et al. Inhibition of inflammation by pentosan polysulfate impedes the development and progression of severe diabetic nephropathy in aging C57B6 mice. Lab Invest. 2011 Oct;91(10):1459-71.

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