| Description | Polyethylene glycol 12-hydroxystearate (Solutol HS-15) is a permeability enhancer. |
| In vitro | Polyethylene glycol 12-hydroxystearate在37°C时促进模型蛋白质(胰岛素)通过Calu-3单层从顶侧到底侧的转移。此外，在4°C下，相对于相应的对照组，Polyethylene glycol 12-hydroxystearate存在时胰岛素的渗透性没有统计学上显著增加。经Polyethylene glycol 12-hydroxystearate处理的细胞对较小分子量渗透物(5至22 kDa)显示出统计学上显著的渗透性增加，而对于分子量较大的蛋白质，如白蛋白和IgG，渗透性增加并不显著(P>0.05相对于对照)。 |
| Synonyms | Solutol HS-15 |
| molecular weight | 344.536 |
| Molecular formula | C20H40O4 |
| CAS | 61909-81-7 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | Ethanol: 100 mg/mL, Sonication is recommended. H2O: 25 mg/mL, Sonication is recommended. |
| References | 1. Shubber S, et al. Mechanism of mucosal permeability enhancement of CriticalSorb? (Solutol? HS15) investigated in vitro in cell cultures. Pharm Res. 2015 Feb;32(2):516-27. |
| Citations | 1. Xu L, He D, Wu Y, et al. Tanshinone IIA inhibits cardiomyocyte apoptosis and rescues cardiac function during doxorubicin-induced cardiotoxicity by activating the DAXX/MEK/ERK1/2 pathway. Phytomedicine. 2022: 154471. |