| Description | DSPS (Dioctadecanoylphosphatidylserine) is a glycerophospholipid, an important phospholipid membrane component that plays a key role in cell cycle signaling. DSPS can regulate cellular activity and mediate apoptosis. DSPS is widely used as a nutritional supplement. |
| In vitro | 方法：巨噬细胞 RAW264.7 用含有 DSPS (0%-95%) 的 LNP (10-50 µM) 处理 24 h，使用 Flow Cytometry 检测 Bodipy FL 阳性细胞。结果：在没有 DSPS 的情况下，10 µM 的 LNP 仅能转染约 27% 的细胞。当 LNP 分别含有 20%、45%、60% 和 95% 的 DSPS 时，Bodipy FL 阳性细胞的百分比分别增加到 66%、76%、82% 和 85%。[1] |
| Synonyms | DSPS (From soybeans), Phosphatidylserine(36:0), 磷脂酰丝氨酸, Dioctadecanoylphosphatidylserine, Distearoyl phosphatidylserine |
| molecular weight | 792.07 |
| Molecular formula | C42H82NO10P |
| CAS | 51446-62-9 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | H2O: Insoluble DMSO: 7.92 mg/ml (10 mM) |
| References | 1. Bressy C, et al. Inhibition of c-Rel expression in myeloid and lymphoid cells with distearoyl -phosphatidylserine (DSPS) liposomal nanoparticles encapsulating therapeutic siRNA. PLoS One. 2022 Dec 15;17(12):e0276905. 2. Martin KR, Kantari-Mimoun C, Yin M, Pederzoli-Ribeil M, Angelot-Delettre F, Ceroi A, Grauffel C, Benhamou M, Reuter N, Saas P, Frachet P, Boulanger CM, Witko-Sarsat V. Proteinase 3 is a phosphatidylserine binding protein which affects the production and function of microvesicles. J Biol Chem. 2016 Mar 9. pii: jbc.M115.698639. [Epub ahead of print] PubMed PMID: 26961880. 3. Majumder R, Koklic T, Rezaie AR, Lentz BR. Correction to Phosphatidylserine-Induced Factor Xa Dimerization and Binding to Factor Va Are Competing Processes in Solution. Biochemistry. 2016 Mar 15;55(10):1554. doi: 10.1021/acs.biochem.6b00112. Epub 2016 Mar 4. PubMed PMID: 26943353. |