| Description | Polaprezinc is an bioavailable chelate comprised of zinc and L-carnosine, known for its gastrointestinal protective properties, as well as its anti-ulcer, antioxidant, and anti-inflammatory effects. |
| Animal experiments | Male C57BL/6J mice (8-weeks-old; weight, ~20 g). The mice are acclimated for 7 days. They are housed 4-5/cage and fed a laboratory rodent pellet formula and tap water ad libitum. Mice are maintained at a constant temperature of 22°C±0.5°C, a humidity of 50%±5% and are exposed to 12 h light/dark cycles. The mice orally receive 100 mg/kg body weight Polaprezinc in the drinking water. The mice are irradiated at a dose rate of ~200 cGy/min using a 150 kVp X-ray unit. For dosimetry, a probe connected to an electrometer system is placed close to the target site. |
| Synonyms | Zinc L-carnosine, 聚普瑞锌, L-肌肽锌 |
| molecular weight | 289.61 |
| Molecular formula | C9H12N4O3Zn |
| CAS | 107667-60-7 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | H2O: Insoluble DMSO: Insoluble |
| References | 1. Odawara S, et al. Polaprezinc protects normal intestinal epithelium against exposure to ionizing radiation in mice. Mol Clin Oncol. 2016 Oct;5(4):377-381. |