| Description | pNNP (Nitrophenylphosphate) can be used as a substrate for the PP2C assay. pNNP inhibits β-carbonic anhydrase and α-carbonate dehydrogenase, as well as H. pylori Helicobacter pylori. pNNP is a weakly active, tissue-nonspecific alkaline phosphatase modifier. pNNP has been shown to inhibit β-carbonic anhydrase and α-carbonate dehydrogenase. |
| Synonyms | p NNP, p-Nitrophenyl phosphate, p-NNP, Nitrophenylphosphate |
| molecular weight | 219.09 |
| Molecular formula | C6H6NO6P |
| CAS | 330-13-2 |
| Storage | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 60 mg/mL (273.86 mM) |
| References | 1. Culbreth PH, et al. 4-Nitrophenol in 4-nitrophenyl phosphate, a substrate for alkaline phosphatase, as measured by paired-ion high-performance liquid chromatography. Clin Chem. 1977;23(12):2288-2291. 2. Innocenti A, et al. Paraoxon, 4-nitrophenyl phosphate and acetate are substrates of α- but not of β-, γ- and ζ-carbonic anhydrases. Bioorg Med Chem Lett. 2010;20(21):6208-6212. 3. Jheng NY, et al. Co(I) complexes with a tetradentate phenanthroline-based PNNP ligand as a potent new metal-ligand cooperation platform. Dalton Trans. 2020;49(41):14592-14597. 4. Schotes C, et al. Asymmetric Diels-Alder reactions of unsaturated beta-ketoesters catalyzed by chiral ruthenium PNNP complexes. J Am Chem Soc. 2010;132(11):3652-3653. |