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PKC-theta inhibitor 1

CAS No.: 1160501-81-4

PKC-theta inhibitor 1 is an inhibitor of PKCθ (Ki of 6 nM)
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Description PKC-theta inhibitor 1 is an inhibitor of PKCθ (Ki of 6 nM)
Target activity PKCα:1020 μM (ki), PKCδ:392 μM (ki), PKCθ:6 nM (ki), IL-2 production:0.19 μM
molecular weight 348.32
Molecular formula C17H15F3N4O
CAS 1160501-81-4
Storage Powder: -20°C for 3 years | In solvent: -80°C for 1 year
References 1. Collier PN, et al. Discovery of Selective, Orally Bioavailable Pyrazolopyridine Inhibitors of Protein Kinase Cθ (PKCθ) That Ameliorate Symptoms of Experimental Autoimmune Encephalomyelitis. ACS Med Chem Lett. 2019 Jun 27;10(8):1134-1139.